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P A P E R SPurpose: To assess the significance of patient age, tumor-related prognostic parameters, status of surgical excision margins and Sunday, April 27, 2003 irradiation boost on incidence of ipsilateral breast relapse (IBR). 9 :0 0 -9 :3 6 AM Materials and Methods: Records of 1, 039 T1 and 308 T2 carcinomas of the breast treated with conservation therapy were coded: B R E A S T PA P E R SIn the T1 tumors 30 (3%) had positive excision margins and 40 1. Effects of Breast Conserving Therapy on Lactation after Pregnancy:(4%) close margins (3mm). The mean follow up for surviving An Update of the Yale Experience patients was 6.6 years (range 3-30). Results: The actuarial 10-year incidence of IBR was 8% for T1 and CT 12% for T2 tumors. In patients 40 years or younger, 4/24 (17%) with extensive intraductal component (EIC) developed a IBR com-Purpose: To evaluate lactation outcomes in early stage breast cancer pared to 6/80 (8%) without EIC, compared to 8/159 (4%) and patients treated with breast conserving therapy (BCT). 33/776 (4%) in post-menopausal patients with or without EIC respectively (P 4 0.03). The incidence of IBRs in T1 tumors were 1/30 (3.3%) for positive, no relapses in 40 with close margins, 16/ Materials and Methods: A review of our breast cancer database 438 (3.6%) for negative and 18/196 (9%) undetermined margins. of over 3, 000 patients was conducted to identify a subgroup of With T2 tumors IBRs occurred in 12.5%, 6% , 6.6% and 5.9% premenopausal women who underwent BCT and who subsequently respectively. In patients with T1 tumors, negative margins, the sustained full term pregnancies. This subgroup became the focus IBR rate was 8% with or without a boost. Patients with positive of our study. All patients were treated at the radiation therapy margins (receiving 18-20 Gy boost) the IBR was 4% with a boost facilities of the Department of Therapeutic Radiolo Gy, Yale New and 33% without it (P 4 04). With T2 tumors, negative margins Haven Hospital. Lactation data was collected from the patients' IBR was 10% with a boost and 12% without it (P 4 48). With departmental and hospital records and through interviews with the T2 tumors, close or positive marginsIBR was 12% with a boost and patient and family members. 40% without it.(p0.01). On multivariate analysis only age and adjuvant therapy were significant factors predictive of IBR. Results: Twenty-eight pregnancies were identified in 21 patients who underwent BCT for early stage breast cancer. The median Conclusions: Surgical excision margins status following adequate age at diagnosis was 32. One patient underwent bilateral BCT prior doses of radiation therapy is not a predictor of IBR. In patients to her pregnancy, therefore, a total of 22 breasts were irradiated. younger than 40 years of age with EIC a somewhat higher breast The median dose to the breast was 5000 c Gy with a median boost relapse rate was noted. Correlation of surgical margin status and of 1100 c Gy with electrons (21 breasts) or implant (1 breast). All irradiation doses decrease I...