Objectives : Theserumcreatinekinase(CK)levelofAmyotrophicLateralSclerosis(ALS)patients suggeststhatitmaybeanindependentprognosticfactorforthesurvivalofALS.Wereport thechangesofserumCKlevelofALSpatientstreatedbyadministeringprocessedGlycyrrhiza uralensis extractsandKoreanmedicaltreatments. Methods : WeprovidedanALSpatientwithprocessedGlycyrrhizauralensis extractsandKorean medicaltreatmentsincludingacupuncture,pharmacopunctureandherbalmedicine.Theserum CKlevelwascheckedeverymonth.ThechangesofALSFRS-RandMRCgradewerechecked everymonthforadditionalresult. Results : TheserumCKlevelastheprognosticfactorforthesurvivalofALSgraduallydecreased forthreemonths.However,ALSFRS-Rdecreasedbytwopointsatthesecondtrial.MRCrate hadnochangeforthreemonths. Conclusion : CombinedadministrationofprocessedGlycyrrhizauralensis extractsandKorean medicaltreatmentcouldbemeaningfulpossibilitiesinthetreatmentofALS.Weshouldconduct furtherstudiestosolvethelimitationsofthiscasestudy.

Objectives : Amyotrophic lateral sclerosis(ALS) is a progressive neurodegenerative disorder characterized by a selective death of motor neuron, leading to respiratory insufficiency. The purpose of this study was to assess the long term respiratory management of ALS patient with respiratory failure. Methods : One ALS patient applying a non-invasive BIPAP ventilator as well as Korean medical treatment such as acupuncture, pharmacopuncture and herbal medicine was measured on SpO2, EtCO2, Vte(expiratorytidalvolume) for 2 years 7 months. Results : The SpO2, EtCO2 of ALS patient were maintained in the normal range for 2 years 7 months. The Vte of ALS patient also wasn't worse in this study. Conclusions : In this study, the long term respiration management, combined administration of Korean medical treatment and non-invasive BIPAP ventilator, could be effective in ALS patient with respiratory failure.

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