The purpose of this research is to examine the influence to physical health status, economic status, family support, social support and self-esteem which affects to solve depression, and give basic information for developing a program to prevent the aged people gloominess and a way to solve that gloominess. This surveying study was undertaken through personal interview way for 357 aged people who were in the elder's meeting hall, living in elderly welfare institude, or home near Gumi, Gimcheon, and Chilgok regions. For data analysis, SPSS/PC 18.0 and AMOS 18.0 program for frequency analysis, First, In the reason of depression by general distinctive quality, there was a significant difference in sex`educational background`existance of a spouse of the condition of living-together, and personal health condition. Second, affecting factors to religious life were economic condition, family support, and self-esteem. Third, the most serious factor that enhanced depression was physical health. Fourth, It appeared as higher attendence of indivisuals about religion means decrease of the depression. When these result reviewed, to control the depression of aged people, it is necessary to develop and conduct a total program that can detect and manage depression early through measuring the physical health, family support, social support and self-esteem. Especially, participation of religious life is considered to ameliorate the depression of aged people and help them live a good senescence.■ keyword :|Aged People|Religious Life|Depression|

Pectolinarin, [5,7-Dihydroxy 4 ′ ,6-dimethoxyflavone 7-rutinoside, 7-[[6-O-(6-Deoxy-α-Lmannopyranosyl)-β-D-glucopyranosyl] oxy]-5-hydroxy-6-methoxy-2-(4-ethoxyphenyl)-4H-1-benzopyran-4-one], has been stated one of the major compounds in Cirsium nipponicum (Maxim.) Makino. It is characterized by biological functions of hepatoprotective, anti-inflammatory and antiobesity activities. In this research, it was explained that pectolinarin causes apoptosis in PC12 cells conducted by DNA fragmentation and formation on apoptotic bodies through the activation of ER stress sensors (ATF6 fragmentation and eIF2α phosphorylation). The result of treating the PC12 cells with 50 µM pectolinarin for 24 h has come to increase ATF6 mRNA expression up to 1.6 times, PERK expression up to 1.7 times and IRE1 expression up to 1.4 times, respectively, compared to those of the control. ATF6 fragmentation by pectolinarin treatment was increased about 2 times compared with its control, and phosphorylation of eIF2α was increased 2.5 times. The results proposed that the perception of the molecular mechanisms underlying pectolinarin-caused apoptosis may be useful in new natural medicinal products and health supplements for the apoptosis-related diseases.

Cyclophilin A (CypA), a cytosolic binding protein of cyclosporine A, is an immunosuppressive drug. In this study, CypA cDNA was cloned from the two-spotted cricket Gryllus bimaculatus (gCypA). The protein encoded by gCypA comprises 165 amino acids with a molecular mass of 19.23 kDa and an isoelectric point of 9.38 and possesses three N-glycosylation sites and 17 phosphorylation sites. The secondary and tertiary structures of gCypA were identified, and homology analysis revealed that it shares around 73%-81% sequence identities with other CypA proteins. When the researchers analyzed the expression levels of gCypA mRNA in various tissues, they found that the foregut exhibited nearly the same expression level as that of the dorsal longitudinal flight muscle (the control). However, gCypA mRNA expression in the fat body, Malpighian tubes, and midgut was less than half of that in the dorsal longitudinal flight muscle. Under endoplasmic reticulum stress conditions, gCypA mRNA expression was highest in Malpighian tubules (about two times higher than the expression in the control). Under starvation conditions, gCypA mRNA expression increased to three times that of the dorsal longitudinal flight muscle 6 days after starvation. Nonetheless, its expression levels decreased in Malpighian tubules under all starvation conditions. This study provides insights into the physiological role of gCypA in G. bimaculatus.

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