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Atopic dermatitis, one of the most important skin diseases, is characterized by both skin barrier impairment and immunological abnormalities. Although several studies have demonstrated the significant relationship between atopic dermatitis and immunological abnormalities, the role of hydroxyeicosatetraenoic acids (HETE) in atopic dermatitis remains unknown. To develop chiral methods for characterization of 12-HETE enantiomers in a 1-chloro-2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model and evaluate the effects of 12-HETE on atopic dermatitis, BALB/c mice were treated with either DNCB or acetone/olive oil (AOO) to induce atopic dermatitis, after which 12(R)- and 12(S)-HETEs in the plasma, skin, spleen, and lymph nodes were quantified by chiral liquid chromatography-tandem mass spectrometry. 12(R)- and 12(S)-HETEs in biological samples of DNCB-induced atopic dermatitis mice increased significantly compared with the AOO group, reflecting the involvement of 12(R)- and 12(S)-HETEs in atopic dermatitis. These findings indicate that 12(R)- and 12(S)-HETEs could be a useful guide for understanding the pathogenesis of atopic dermatitis.

BACKGROUND: Kiwifruit, which was introduced to Korea in late 1970s, is a warm-temperate fruit tree, whose leaves are easily damaged by wind because of their large size. To produce high quality fruits, efficient windbreak is necessary to protect leaves until harvest. In Korea, typhoons from July onwards usually influence the production of kiwifruit. Damages from typhoons include low fruit quality in the current year and low flowering ratio the following year. This study was conducted to investigate the effect of early defoliation of kiwifruit vines from July to October on the regrowth of shoot axillary buds the current year and bud break and flowering the following year. METHODS AND RESULTS: Scions of kiwifruit cultivar 'Goldrush' were veneer grafted onto five-year-old Actinidia deliciosa rootstocks, planted in Wagner pots (13L) and

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A new Saxifraga fortunei cultivar 'Foxstar' was bred by crossing between 'Hongsaja' with red purple (RPN66A) colored petals and 'Yoangwoo' with light pink (RPN57C) colored petals. The selection and flower characterization were conducted from 2004 to 2008 in greenhouse of Highland Agriculture Research Center, NICS, RDA. The flowering of 'Foxstar' occurred from October 5 for 28 days, The number of flowers per plant was 160.0 with many flowering habit. The flower shows dark pink (RPN66B) color at the opening, The number of petals were 6.1, with a width of 1.9cm and length of 2.1 cm. The plant height was 12.6 cm, and number of flower stem was 10.2, and number of leaves per plant was 84.0. 'Foxstar' cultivar can be used for pot flower. Fifty percent shading is a good cultural practice against direct sunlight and soft rot disease would occurs usually by over-irrigation.