AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e., HIV-1 protease, HIV-1 reverse transcriptase and HIV-1 integrase [IN]) of the viral replication cycle, HIV-1 IN has been of particular interest due to the absence of human cellular homolog. HIV-1 IN catalyzes the integration of viral genetic material with the host genome, a key step in the viral replication process. Several novel classes of HIV IN inhibitors have been explored by targeting different sites on the enzyme. This review strives to provide readers with updates on the recent developments of HIV-1 IN inhibitors.

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A Ab bs st tr ra ac ct tIn the construction operation, foundation work should be done in advance for the building structure to be installed. This foundation work include a number of activities such as excavation, ground water prevention, piling, wale installation, etc. Caution should be taken in the operation because the dynamics of earth movement can cause a significant failure in the temporary structure. The temporary structure, therefore, should be constantly monitored to understand its behavior. This paper introduces the USN-based monitoring system to automatically identify the behavior of the temporary structure in addition to visual inspection. The autonomous capability of the monitoring system can increase the safety in the construction operation by providing the detailed structural changes of temporary structures.