Relationship between fatigue, physical activity and health-related factors in COPDFatigue is highly prevalent in COPD and may be associated with reduced physical activity (PA) and poor outcomes. This study explored the relationship between fatigue, objectively measured PA and health-related factors in people with COPD.Fatigue was assessed with the Checklist of Individual Strength (CIS20) and CIS20-Subjective Fatigue (CIS20-SF) and PA with Actigraph GT3X monitors (moderate-to-vigorous PA, MVPA; total PA; steps/day). Dyspnoea (modified Medical Research Council, mMRC), exercise tolerance (6min walk distance, 6MWD), lung function (spirometry) and GOLD classification A-D were collected. Spearman (ρ) and Pearson (r) correlations and multiple regressions were performed. Variables entered the model if correlation≥0.2. 54 patients participated (68±7yrs; 82% men) and 69% reported fatigue (CIS20-SF≥27). Fatigue was significantly correlated with MVPA, steps/day, mMRC, 6MWD, GOLD A-D and FEV1pp (Table 1). In regression models for CIS20 (p=.001; r 2 =.37) and CIS20-SF (p=.003; r 2 =.31), dyspnoea was the only significant variable.People with higher scores of fatigue present lower PA levels, although the relationship is weak. Dyspnoea appears to have the largest influence on fatigue.