Objective: To understand the feelings and difficulties experienced by cancer patients in relation to the diagnostic and therapeutic itineraries. Methods: An exploratory study of a qualitative nature, developed with 13 people with cancer, through an interview. In the period from June to September of 2017 data were collected and later submitted to content analysis. Results: The results included the unpleasant feelings that patients with cancer experience, and the recognition of factors that influence the re-signification of this phase. In addition, we observed the difficulties that perpass the routine of treatment and that compromise the basic needs of these individuals. Final considerations: It was understood that during the experience of the diagnostic and therapeutic itinerary, people with cancer experience negative feelings and many difficulties. However, some factors make possible the resignification of the disease and need to be considered by health professionals and managers to minimize the impact of the disease during this journey.