Headache and vomiting are the earliest and commonest symptoms in children with brain tumors. Visual symptoms and signs and behavioral change are often present. Abnormalities in neurological examination are reported in most of the children. Intracranial hypertension symptoms suggest the need for a neurological clinical examination and an ophthalmological assessment.
To our knowledge, this is the first case of a non-anaplastic PXA presenting with disseminated disease. Thus, it was thought important to describe this case in order to add further information regarding the spectrum of the presenting clinical features of this rare neoplasm and the phenomenon of LMD of non-malignant glioma.
Background
Cerebellar tumor survivors often exhibit neuropsychological deficits that could be related to alterations in cerebro‐cerebellar networks. This is a pilot study designed to understand if diffusion tensor imaging (DTI)‐based tractography is able to identify possible correlations between cerebellar white matter structure and cognitive outcome in children on long‐term follow‐up for posterior fossa (PF) tumors who were thoroughly assessed for neuropsychological functioning.
Methods
DTI‐based tractography was performed in pediatric patients with PF tumors. Fractional anisotropy (FA) and volumetric measurements of spinocerebellar, dentorubrothalamocortical and corticopontocerebellar tracts were analyzed. Cognitive and neuropsychological functioning was assessed by the Wechsler Intelligence Scale for Children–IV Edition (WISC‐IV) and the Developmental Neuropsychological Assessment (NEPSY II). The associations between Full‐Scale Intelligence Quotient (FSIQ), NEPSY‐II scores, and fiber tracts were tested by the Spearman rank correlation coefficient.
Results
Seven patients (median age at diagnosis five years, range, 3‐13) treated for medulloblastoma (2/7; 29%) and pilocytic astrocytoma (5/7; 71%) were retrospectively evaluated. All children had complete surgery. The median FSIQ was 84 (range, 67‐93). Patients presented with several deficits on many NEPSY‐II tasks; in particular, memory was impaired in nearly half of them. FSIQ and neurocognitive tasks significantly correlated with specific corticopontocerebellar tracts.
Conclusion
Children on follow‐up for PF tumor showed scattered cognitive impairments, including deficits in long‐term and immediate memory. Tractography allowed us to describe a possible association between the integrity of cerebellar pathways and neurocognitive performance, suggesting that the myelinization of these fibers may represent an indicator for the development of long‐term cognitive sequelae.
Aim
Children and adolescents affected by somatization and somatic symptom disorder commonly refer to emergency services. Due to the absence of specific guidelines for the emergency setting and to a possible lack of knowledge, these patients are at risk of being unrecognized and mismanaged. This study aims at proposing a clinical practice to approach and manage these patients and their families in the emergency setting.
Methods
This manuscript derived from the work of a research group of italian pediatric emergency physicians and anesthesiologists, with an expertise in pain management, members of the PIPER group. The research group reviewed the literature about psychosomatic pain and somatic symptom disorder and developed a clinical practice specific for the pediatric emergency setting.
Results
The manuscript provides information about the main clinical features shared by patients with psychosomatic pain and about current diagnostic criteria and appropriate management in the emergency setting. Furthermore, it highlights the possible pitfalls in which the emergency physician may run into dealing with these patients.
Conclusion
This clinical practice should be seen as a starting point toward a better understanding of patients with psychosomatic pain and a standardization of care in the pediatric emergency setting.
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