Throughout the last decades the developments on desalination field have been focused on energy consumption and costs reduction. However, water recovery and brine disposal are becoming a matter of concern to desalination industry. In this work, a Zero Liquid Discharge (ZLD) unit coupled with a Solar Micro Gas Turbine (SMGT) system is presented to address, among others, the challenges of mining industry in remote areas, in particular, fossil fuel dependence, water availability and pollution derived from effluents disposal. As a way to assess the feasibility of the proposal, a techno-economic analysis of the application in two Southern American regions (Chile and Ecuador) of photovoltaic modules, wind turbines and Solar Micro Gas Turbines is performed. Afterwards, the main novel feature of the new system—i.e., the ZLD unit—is described and a sensitivity analysis on its functioning whilst coupled with the SMGT is carried out. The aim is to propose a preliminary design of the ZLD process. The selection of the optimal ratio between exhaust gases and brine mass flow rates is analyzed, as well as variation in inlet salinity and temperatures. Furthermore, the water which could be recovered from effluents, at the same time that the heat of exhaust gases from SMGT is harvested, is quantified. Lastly, according to the results obtained, a preliminary design of a 10 kWe rated power SMGT system, coupled to Reverse Osmosis (RO) and ZLD units, is proposed.