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Pregnant individuals are susceptible to maternal mpox (monkeypox) infection and are eligible for treatment. Although transplacental transmission of mpox is possible, this case did not result in fetal infection.

HighlightsNon-gestational choriocarcinomas are a rare presentation of germ cell tumors.In rare cases, choriocarcinoma can present from the de-differentiation of gastrointestinal adenocarcinomas.There are only 5 reported cases of choriocarcinoma de-differentiated from a gastric or esophageal primary lesion.No evidence-based treatment protocol exists for this presentation and all reported cases have poor outcomes.

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