No abstract

In this neonatal group with intractable bleeding and/or severe coagulation disturbances, rFVIIa was more effective in early intervention as rescue therapy, without any adverse events in all neonates. Upon failure to achieve hemostasis with initial administration of blood products, fast intervention with rFVIIa could be considered in neonates with serious bleeding and coagulation disorders.

Advances in neonatology enabled significant improvements in neonatal survival, often at the expense of long-term morbidity. End-of-life decisions concern neonatal patients with fatal congenital anomalies, severe neurological deficits, and extreme prematurity at the limits of viability, presenting a complex issue for both healthcare professionals and parents. Since newborns cannot express their wishes or claim their rights, physicians and parents carry the responsibility to decide in their best interests, considering their future quality of life. Harmonization of scientific progress and legislation defining clear rules is necessary so neonatologists can proceed to such agonizing decisions. Greece lacks both specific legislation regarding such decisions and medical training on handling respective ethical dilemmas. Thus, guidelines improving such decisions are closely related to the quality of the healthcare system and should be established along with the legal system's adaptation.

Advances in neonatology enabled significant improvements in neonatal survival, often at the expense of long-term morbidity. End-of-life decisions concern neonatal patients with fatal congenital anomalies, severe neurological deficits, and extreme prematurity at the limits of viability, presenting a complex issue for both healthcare professionals and parents. Since newborns cannot express their wishes or claim their rights, physicians and parents carry the responsibility to decide in their best interests, considering their future quality of life. Harmonization of scientific progress and legislation defining clear rules is necessary so neonatologists can proceed to such agonizing decisions. Greece lacks both specific legislation regarding such decisions and medical training on handling respective ethical dilemmas. Thus, guidelines improving such decisions are closely related to the quality of the healthcare system and should be established along with the legal system's adaptation.