Regions are increasingly being viewed as eco-systemic agglomerations of organizational and institutional entities or stakeholders with socio-technical, socio-economic, and sociopolitical conflicting as well as converging (co-opetitive) goals, priorities, expectations, and behaviors that they pursue via entrepreneurial development, exploration, exploitation, and deployment actions, reactions and interactions. In this context, our paper aims to explore and profile the nature and dynamics of the Quadruple/Quintuple Helix Innovation System Model or Framework (government, university, industry, civil society, environment) as an enabler and enactor of regional co-opetitive entrepreneurial ecosystems which we conceptualize as fractal, multi-level, multi-modal, multi-nodal, and multi-lateral configurations of dynamic tangible and intangible assets within the resource-based view and the new theory of the growth of the firm. Co-opetitive fractal innovation and entrepreneurship ecosystems are defined and discussed, and examples of regional innovation 148 V C 2017 RADMA and John Wiley & Sons Ltd policies and programs are presented. Furthermore, the concept of multi-level innovation systems is analyzed, taking into account the existence of knowledge clusters and innovation networks, while alternative aggregations of multi-level innovation systems are proposed based on their spatial (geographical) and non-spatial (research-based) functional properties.

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Purpose Organizations and their members operate in increasingly complex, dynamic and even disruptive environments, with risk and uncertainty being major challenges. To that effect, data, information, knowledge, and respective competences are increasingly instrumental in enabling and sustaining organizational intelligence that translates into resilience in the shorter and sustainable excellence in the longer term. Therefore, the purpose of this paper is to explore the role of the artifacts and routines in a sustainable organizational excellence context. Design/methodology/approach An extensive literature review was used to develop the context of the paper, focusing on big data and organizational intelligence for enterprise excellence and resilience. In addition, a thematic literature review method was used to study the role and impacts of routines and artifacts in organizational change, policies, structure and performance. Findings Although many traditional management practices retain their validity, knowledge management must give a clearer view of the existing connection between firm-level competitive advantage in open economies flows and difficult-to-use knowledge assets. The proposed framework studies knowledge exploration and knowledge exploitation as organizational phenomena opposed and mutually incompatible. Originality/value The paper presents a first attempt to study the linkages of organizational routines and artifacts as a cycle wherein knowledge acquisition and learning competencies form and enhance a firm’s organizational intelligence, leading to robust competitiveness and sustainable entrepreneurship.