Aim to analyze and compare the effectiveness of conservative treatment and complex methods (intravitreal injections of angiogenesis inhibitors and retinal laser coagulation) of the central retinal vein occlusion treatment. Material and methods. Based on the case histories, there were analyzed the results of central retinal vein occlusion treatment in 40 patients (the average age is 63) who were treated at the Republican Ophthalmological Hospital. Results. The course of combined therapy including the anti-VEGF injections and retinal laser coagulation showed the best results: a more significant and persistent decrease of retinal edema and a more marked increase of visual acuity, if compared to conservative therapy of the central retinal vein occlusion. Conclusion. The results obtained allow us to recommend the complex treatment of the central retinal vein occlusion as the best method for fast and persistent elimination of retinal edema, increased visual acuity and prevention of complications.