<p>Elevated  cholesterol  level is one of  the risks  for cardiovascular disease  in diabetes mellitus. Exercise is one of therapy in patients with diabetes mellitus. The purpose of this study is to determine the effect of exercise on decrease cholesterol levels in patients with diabetes mellitus. This study used pre-post test one group design. Twenty-two patients with diabetes mellitus followed the intervention which is a twice a week exercise for 4 weeks. Cholesterol levels were measured before and after exercise. Data were analyzed by  dependent T-test. Cholesterol  levels in patients with  diabetes  mellitus before  the exercise reached 261.18±49.013 mg/dL and after intervention decreased to 224.41±26 mg/dL. Dependent t-test showed differences in cholesterol levels before and after exercise in patients with diabetes mellitus (p&lt;0.05). Exercise can lower cholesterol levels in patients with diabetes mellitus.</p>