Centella asiatica (CA) is herbal medicine that used as traditional medicine including ayurvedic theraphy since hundreds years ago. This herb containa of pentacyclic triterpenoids such as asiaticoside, madecassoside, Asiatic acid and brahmoside that proved had anti-oxidant and anti-inflammatory properties. This research aims to know the effect of ethanolic extract of CA extract against the length of rotenone-induced zebrafish larvae through the free radicals.mechanism. This research used zebrafish larvae until 6 dpf that consists of 5 groups (controls, rotenon 12.5 ppb on 2 hpf-3 dpf, and group treatment given rotenone 12.5 ppb 2 hpf-3 dpf and 5 µg/mL extract with long exposure to start 2 hpf to 4, 5 and 6 dpf respectively). The body length measured on 3-6 dpf using software Image Raster v 3.0 from optilab v 2.0. Malondialdehyde (MDA), superoxide Dismutase (SOD), catalase were measured by ELISA on 6 dpf. The results showed rotenon can inhibit the growth of length > 2 standard deviation (SD) and CA extract may increased ithe body in 6 dpf which correction value was 99.6%. CA extract significantly decreased the levels of MDA, and increased the level of SOD and catalase (p=0.000). Ethanol extract of Centella asiatica may increase in length through the modulation of oxidative stress.

Background: Dysmenorrhea can affect women who experience menstruation at any age. There is no age limit. Almost all women experience discomfort during menstruation, usually accompanied by nausea, dizziness, and even fainting. If it's like this, of course, menstrual pain should not be left alone. This dysmenorrhea can be overcome by pharmacological and non-pharmacological approaches. One of the non-pharmacological approaches that can be used is hypnotherapy.Objective: To determine the comparison of the level of menstrual pain (dysmenorrhea) before and after hypnotherapy in adolescent girls.Method: The method used in this literature review study is to obtain from a search of scientific research articles from the 2015-2020 period using the Google Scholar and Pubmed data bases. A total of 187 articles were obtained and then identification and screening were carried out, so that 10 articles were obtained that matched the inclusion criteria.Results: The average of the articles shows a pValue value <0.005 which means that there is a significant comparison and difference between before being given the intervention and after being given the intervention.Conclusion: There is a comparison of the level of menstrual pain (dysmenorrhea) before and after hypnotherapy in adolescent girls. It is recommended for educational institutions to provide information to all young women about hypnotherapy to reduce menstrual pain (dysmenorrhea).

Prevalensi stunting di Indonesia masih cukup tinggi yaitu mencapai 32,8% pada baduta. Meski terjadi penurunan prevalensi stunting tahun 2018 baik pada balita maupun baduta namun masih belum mencapai target yang diharapkan. Salah satu upaya untuk percepatan penurunan prevalensi stunting yaitu melalui pendidikan dan deteksi dini stunting pada anak. Tujuan kegiatan pengabdian yaitu untuk meningkatkan pengetahuan masyarakan khususnya orang tua baduta agar melakukan pengukuran panjang badan secara berkala pada anak sebagai upaya deteksi dini stunting. Metode yang digunakan berupa ceramah untuk memberikan edukasi tentang stunting dan praktik deteksi dini stunting dengan cara pengukuran antropometri. Kelompok sasaran adalah ibu baduta yang berjumlah 25 orang. Monitoring dan evaluasi diukur pada aspek perubahan pengetahuan, menggunakan kuisioner dan wawancara. Keberhasilan kegiatan diukur dan dianalisis menggunakan Paired T-test. Hasil analisis menunjukkan adanya perubahan pengetahuan setelah mendapatkan edukasi tentang stunting (p= 0,000). Hal tersebut menunjukkan bahwa adanya perbedaan pengetahuan yang signifikan antara pre dan post pemberian edukasi kelompok sasaran. Hasil pengukuran panjang badan terjaring 12% baduta dengan panjang badan >-2 SD. Kegiatan pengabdian ini dapat dijadikan langkah awal untuk memberdayakan masyarakan dalam mendeteksi secara dini stunting pada baduta dan dapat dilakasanakan secara berkelanjutan kedepannya.

BACKGROUND: The prevalence of preeclampsia cases in the province of Aceh has increased every year. This case in West Aceh District has increased from year to year in pregnancy that can have adverse effects on both the mother and the fetus. AIM: Analyzing risk factors for the incidence of preeclampsia in pregnant women in the working area of the Meureubo and Johan Pahlawan Puskesmas, Aceh Barat district. METHODS: This was an analytic observational study with a case-control study design. The study population was pregnant women in Meureubo and Johan Pahlawan subdistricts of Aceh Barat district. The sample selection is purposive sampling, amounting to 42 people – bivariate data analysis using the Chi-square test. RESULTS: There is a significant relationship between the knowledge factor and preeclampsia incidence with a p = 0.029 < 0.05. The analysis results obtained an odds ratio (OR) = 0.171, which means that pregnant women with inadequate knowledge have a 0.171 fold risk of developing preeclampsia. There is a significant relationship between the incidence of hypertension and preeclampsia incidence in pregnant women with a p = 0.009 < 0.05. The analysis results obtained an OR = 2.50, which means that pregnant women who have a history of hypertension have a 2.50 times risk of experiencing preeclampsia compared to other pregnant women. The variables of age, parity, food consumption, and history of diabetes mellitus were not significantly associated with preeclampsia incidence in pregnant women with p > 0.05. CONCLUSION: There is a significant effect of providing a self-empowerment-based education package to the elderly on the level of knowledge and oral hygiene status of the elderly in Darul Imarah District, Aceh Besar (p < 0.05).

Centella Asiatica (Linn) Urban is known as Gotu Kola. Centella Asiatica (CA) is rich in micro and macronutrients. The aim of this study was to investigate the effect of ethanol extract of CA on bone ossification and body length in zebrafish larva stunting model at 9 dpf. This study used zebrafish at 2 hpf (hour post-fertilization) - 9 dpf (day post-fertilization). The population of 300 larvae divided into 5 groups consisting of control group, rotenone group (exposed by 12.5 ppb of rotenone) and 3 rotenone+CA groups that exposed to CA extract for 4, 5 and 6 days,  respectively. The CA extract was obtained by maceration method with ethanol solvent. The results showed that rotenone 12,5 ppb able to inhibit the growth of larvae >2SD of body length and decrease bone ossification at rotenone group, were significantly different from the control group. Administration of CA extract was increased expression of cartilage at rotenone+CA5 as well rotenone+CA6 group and increase expression of bone at the rotenone+CA5 group and also increase body length rotenone+CA groups significantly different from rotenone group. It can be concluded that the period of CA extract exposure can correct the length of the body reaching 99.6% at 9 dpf and increased bone ossification in a time-dependent manner.Centella asiatica (Linn) Urban dikenal dengan nama pegagan. Centella Asiatica (CA) kaya akan mikro maupun makro nutrisi yang diperlukan bagi tubuh terutama masa pertumbuhan. Penelitian ini bertujuan mengetahui efek ekstrak etanol CA terhadap osifikasi tulang dan panjang badan larva zebrafish model stunting yang diinduksi rotenone pada 9 hari post fertilisasi. Penelitian ini menggunakan zebrafish mulai 2 hpf (hour post fertilisation) - 9 dpf (day post fertilisation), populasi larva sejumlah 300 yang dibagi 5 kelompok yang terdiri dari kelompok kontrol, kelompok rotenon (dipapar rotenone 12,5 ppb) dan 3 kelompok rotenone+CA yang diberikan pegagan selama 4, 5 dan 6 hari secara berurutan. Ekstrak CA diperoleh melalui  metode maserasi dengan pelarut etanol. Hasil penelitian menunjukkan bahwa rotenone dapat menghambat pertumbuhan panjang larva >2SD dan menurunkan osifikasi tulang pada kelompok rotenon secara signifikan dibanding kontrol. Pemberian ekstrak CA dapat meningkatkan ekspresi tulang rawan kelompok rotenone+CA5 maupun rotenone+CA6 dan meningkatkan ekspresi tulang keras kelompok rotenone+CA5 serta meningkatkan panjang badan kelompok rotenone_CA secara signifikan dibanding kelompok rotenone. Dapat disimpulkan bahwa lamanya pemberian ekstrak CA dapat meningkatkan osifikasi tulang dan meningkatkan panjang badan mencapai 99.6% pada 9 dpf.