Hipertrofik skar (HTS), deride yaralanmayı takiben, normal yara iyileşmesi sürecinde, fibröz dokunun kontrolsüz artışı sonucu ortaya çıkmaktadır.Bu yara izleri, uzun süreler boyunca fibroblast kaynaklı hücre dışı matriks [extracellular matrix (ECM)] proteinlerinin ve özellikle kolejinin aşırı birikimi ile
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