Our study confirmed that GREM2 is a candidate gene for tooth agenesis, which mutations can explain, however, only a small fraction of the genetic contribution to the pathogenesis of this anomaly.

Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies characterized by the congenital absence of at least one permanent tooth (excluding third molars). Regarding the essential role of genetic factors in ns-TA aetiology, the present study aimed to identify novel pathogenic variants underlying hypodontia and oligodontia. In a group of 65 ns-TA patients and 127 healthy individuals from the genetically homogenous Polish population, the coding sequences of 423 candidate genes were screened using targeted next-generation sequencing. Pathogenic and likely pathogenic variants were identified in 37 (56.92%) patients, including eight nucleotide alternations of genes not previously implicated in ns-TA (CHD7, CREBBP, EVC, LEF1, ROR2, TBX22 and TP63). However, since only single variants were detected, future research is required to confirm and fully understand their role in the aetiology of ns-TA. Additionally, our results support the importance of already known ns-TA candidate genes (AXIN2, EDA, EDAR, IRF6, LAMA3, LRP6, MSX1, PAX9 and WNT10A) and provide additional evidence that ns-TA might be an oligogenic condition involving the cumulative effect of rare variants in two or more distinct genes.

Introduction. Orthodontic elastics are widely used in orthodontic treatment. It’s been proved that they have advantages such as low cost, ease of use, but also disadvantages, mainly force decay in time and increased entrapment of biofilm. Amount of the force is of extreme significance. This force can be altered by physical or chemical factors. Material and Methods. Latex elastics in 3 different diameters were selected for this study. Each elastic was stretched and placed on hooks that are at specified distances that equal 3 times the diameter of each elastic. The forces produced by stretching was measured using tension gauge and the measurement were taken at specific time intervals of 0h, 3h, 12h, 24h. The same process was repeated for elastics in dry and artificial environment. Results. Elastics in the dry environment showed progressive force decay cause by stretching over time. Just after 3 hours force decay between 6,07% and 8,75% was observed. The biggest loss of force between 13,61 — 16,13 % was measured after 24 hours. Compared to the dry environment, an even more significant force decay was observed in the artificial saliva. After first 3 hours force loss was between 4,99% — 9,22%. The biggest force decay was observed after 24 hours and it was 5 % higher compared to dry environment. Conclusions. 1) The artificial saliva environment and time of exposure to it, have a negative effect on the properties of elastomeric. 2) To maintain the effective orthodontic strength of elastics, they should be replaced every 12 hours.

Utrata zębów mlecznych u dzieci z powodu procesu próchnicowego stanowi nadal problem kliniczny. W celu odtworzenia ciągłości łuków zębowych i przywrócenia okluzji wykonuje się różnego rodzaju protezy dziecięce lub aparaty ortodontyczne, które warunkują dalszy prawidłowy rozwój narządu żucia. Intensywny rozwój technologii cyfrowej stwarza możliwości wykonywania precyzyjnych prac protetycznych i aparatów ortodontycznych z materiałów nowej generacji. Tradycyjne wyciski, służące do wykonania modeli gipsowych,

Auto-aggression can be defined as all actions that aim to inflict mental or physical harm to oneself. It can be caused by a dysfunction of the self-preservation instinct, which can manifest in life-threatening self-mutilation tendencies. Auto-aggression can also be one of the symptoms of psychiatric or emotional dysfunctions such as borderline personality disorder, psychopathy or schizophrenia. A dental appointment, being usually a source of great stress, can induce certain auto-aggressive behaviors as well as dental examination can show some lesions or abnormal changes of anatomical structures in the oral cavity which should be thoroughly examined and treated multidisciplinary according to patient’s behavior.