Background: Oral contraceptive pills (OCPs) are a widely used method of contraception, and use of OCPs is a well-known risk factor for venous thromboembolism (VTE). This study aimed to assess the level of awareness of the association between OCP use and the risk of VTE and the level of knowledge of symptoms and signs of VTE among Saudi females who are users of OCPs. Methods: This cross-sectional study was conducted among the Saudi female population between October and November 2020. Knowledge about VTE risk with the use of OCPs and awareness of VTE symptoms and signs among Saudi females were assessed using a structured online questionnaire distributed through social media platforms. Results: Of 1173 participants, 726 used or had been using OCPs. Only 329 (45%) and 303 (41%) were aware of deep vein thrombosis (DVT) and pulmonary embolism (PE), respectively, as a medical condition, while 312 (43%) were aware of the association of OCPs use with DVT risk. Leg swelling was the most commonly identified symptom of DVT in 297 patients (40%), while shortness of breath was the most common symptom of PE in 331 patients (46%). Conclusion: This study showed that the Saudi female population had a low level of knowledge and awareness of DVT and PE in OCP users. Efforts are needed to increase awareness of these preventable diseases in the Saudi female population.

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