Chronic inflammation is defined as a prolonged and impaired immune response leading to a wide range of physiological and pathological conditions, for instance; abnormalities in nervous system, heart diseases, diabetes, obesity, lung diseases, immunological diseases, and cancer. In order to suppress chronic inflammatory diseases, inflammation should be prevented and treatments without side effects are needed at this time.Traditional medicine and dietary restriction have been used in treatment by people for ages. Today, the WHO (the World Health Organization) data reveals that approximately 60% of the world's population and about 80% of the population of the developing countries have turned to herbal medicines. In this context, nutraceuticals attract attention because of their being safe, economical, easily accessible and in low toxicity, and their usages are gradually increasing.Recently, fisetin, a new flavonoid among nutritional supplements, has attracted considerable attention. Fisetin, a bioactive flavonol found in fruits and vegetables, has chemo-preventive, anti-metastatic, neuroprotective, antioxidant, and anti-inflammatory effects. It is known that the concentration of fisetin is mainly high in strawberries, apples and dates. Studies conducted in cell culture and animal models have shown that fisetin has potential healing effects on diseases by affecting various signal pathways. The effects of fisetin, which is a natural nutritional compound with promising potential, on obesity, cancer, neurological diseases, diabetes and cardiovascular diseases are presented to the attention of researchers with this review in the light of current studies.