The present study was designed to investigate the effects of enzymes (Kemzyme) or antibiotic (Salinomycin) feed additives on haemostatic mechanism and some haemostatic parameters in rabbit bucks.Twenty four rabbit bucks of average age 4 months were used and allocated into 3 equal groups (8/ each); control un-supplemented, Kemzyme and Salinomycin supplemented groups. The supplements were mixed with the ration for 8 successive weeks. Blood samples were collected at the end of the 4 th and the 8 th weeks of the experiment. Results obtained revealed that: 1) Kemzyme supplementation was not associated with any significant alterations in the measured parameters and 2) at the end of the 8 th . week , salinomycin adversely affected the haemostatic mechanism in the form of hypocoagulabe state manifested by a significant increase in PT and APTT with a significant decrease in coagulation factors VII, IX and X activities. It could be concluded that kemzyme is a more safer feed additive .While, salinomycin should not be used for more than 4 weeks to avoid its adverse effect on haemostasis that could be a cause of sudden death resulting in economic losses or rendering the rabbit meat unmarketable due to inter and intramuscular patches of bleeding.