Prolactinoma, the most common secretory pituitary tumor, is found in 100 patients per million. It is responsible for impaired reproductive function in both sexes. Its treatment in the context of fertility restoration gives very satisfactory results. The natural history of these tumors in the gestational period is variable depending on their size with a clinically significative risk ranging from 5 to 30%. Their management is complex, requiring evaluation of the effects of pregnancy on tumor growth and the effects of therapy on embryonic and fetal development. We report the case of 23years patient with a macroprolactinoma and the successful outcome of this tumor during the pregnancy.