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SUMMARY Two fatal cases of cryptococcal meningitis complicating adrenocorticosteroid-treated systemic lupus erythematosus are reported. In one patient who was treated with flucytosine alone, after an initial period of improvement cryptococci resistant to flucytosine were isolated, and subsequent amphotericin B treatment did not alter the progress of the disease. In the second patient, who received both drugs concurrently, resistant cryptococci did not appear and the patient recovered sufficiently to return home. Flucytosine-resistant mutants could be demonstrated in vitro in the original cryptococcal isolates from both patients. The use of flucytosine and amphotericin B in combination is discussed.

salmon calcitonin is unlikely to produce symptomatic relief of the RSDS but might prevent bone mineral loss.