Terumo Cardiovascular Systems has released the X-Coated Capiox RX05 or Baby RX oxygenator. This oxygenator is designed for neonate and infant patient populations. The device was integrated into our current perfusion practice and our clinical observations are described here. The Baby RX has a prime volume of 43 mL with a maximum flow of 1.5 L/min. The integrated hardshell venous reservoir has independent venous and cardiotomy filters, as well as a very low minimal operating level of 15 mL. A variety of options provide exceptional versatility for the device. The Baby RX proves to be a low-prime, high-flow oxygenator, enabling us to use it on a wide range of pediatric patients. It will be a useful tool for reducing our neonate and infant circuit priming volumes.