Synthesis and properties of 2-cyclohexylcarbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino [2,1-a] isoquinolin-4-one, a novel anthelmintic with excellent activity against all species of Schistosomes pathogenic to man and a wide range of cestodes, will be reported.
Durch Acetylierung von (I) zu (II) und anschließende Cyclisierung in Gegenwart starker Basen wird Praziguantel (III), ein Anthelminticum mit ausgezeichneter Wirkung gegen Schistosoma‐Arten und Cestoden, synthetisiert.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.