Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. The investigation is expected to evaluate serum level of betartophien protein in patients with skin break out vulgaris and contrast it with its level in solid control. This is A case -control study, was led on 80 patients isolated into 2 groups:(Group A); 60 patients experiencing skin break out vulgaris, (Group B); 20 obviously sound people of coordinated age and sex. All examined subjects were tried forSerum level of Betatrophin. Higher betatrophien level was altogether connected with higher seriousness higher betatrophien level was fundamentally connected with male sexual orientation, PCOD, hairsuitism, androgenetic alopecia. The betatrophien level in AV bunch was essentially higher when contrasted with control gathering . Betatrophien level was proposed to be autonomous indicator of AV defenselessness and seriousness.