The clinico-pathological findings are reported in a case with persistent vegetative state after multiple cerebral lesions. The lesions are small in size, and are situated at different levels of the CNS, some of them being important in the maintenance of wakefulness and motor initiative. The differential diagnosis and the isolation of such a syndrome are discussed.

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A cerebral biopsy performed in an infant 9 months after accidental poisoning with chlorpromazine was studied. Light microscopy disclosed necrosing encephalopathy, while electron microscopy showed neuronal, glial, myelinic and vascular lesions. The findings in the present study suggest that the various neurologic syndromes appearing in cases of prolonged treatment with neuroleptic drugs and persisting after cessation of therapy would be due to consequent occurrence, in specific areas, of some irreversible cerebral lesions.

The present paper reports the case of a bilateralmultiple vascular thrombosis of the carotid system that appeared in the course of a demyelinating meningoencephalitis, in a 16-year-old patient. The most recent publications concerning vascular thromboses in the young, studied especially by angiography, are reviewed. Particular attention is paid to the importance of the infectious factor in the onset of multiple thromboses in the young.

This paper is a histochemical and ultrastructural study of a case of mucopolysaccharidosis with certain clinical and morphological peculiarities. The patient was a 3-year-old girl with a congenital cataract of the right eye; the onset at the age of one was marked by epileptic seizures, accentuated hypotonia, and progressive psychic degradation. Optical microscopy of a cerebral biopsy specimen revealed ballooning of the neurons, swollen dendrites, vacuolized cytoplasm, and excentric nucleus. PAS staining showed an intensely positive material in the grey matter. Ultrastructural aspects were the presence of lamellar bodies, granulo-membrano-vacuolar bodies, low electron-dense vacuoles, and a special aspect of membranous body conglomerates with a peculiar orientation of the membranes. The presence of nuclear bodies in the astrocytes is described. Listing of this case among the existing classification types is discussed.