The molten organlc salt ethylammonlum nltrate Is shown to be sultable for use as a statlonary phase In gas-liquid chromatography. I t has a usable temperature range of ~4 0 -1 2 0 OC. I t Is shown to behave as a polar llquld wlth a stronger lnteractlon than Carbowax 20M for test compounds having large dlpole or hydrogen-bondlng functlonal groups. The chromatographic properties of the molten salt are illustrated for the separatlon of alcohols and monofunctional benzene derlvatlves. Amlnes are not eluted from the column withln the accessible operatlng temperature range for the stationary phase.

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SummaryThe feasibility of using supercritical fluid chromatography (SFC) for analysis of polar and/or ionic analytes of interest to the pharmaceutical industry is described. Specifically, the analyses of cyclosporin (a cyclic undecapeptide), several ionophores, and a group of fat-soluble vitamins are illustrated. The separation of a group of fat-soluble vitamins is evaluated on two bonded stationary phases, DB-5 (95'/0 dimethyl-5%-diphenylpolysiloxane) and DB-WAX (Carbowax 20M type, "bonded"). Lastly, a new restrictor technology known as a converging-diverging restrictor is described.