The results of the secretin-CCK test were compared with the histological findings of pancreatic tissue resected in 25 patients with chronic pancreatitis. Secretin-CCK test results were interpreted with the use of discriminant analysis, yielding a quantitative score for each patient. Histological findings were recorded according to a semiquantitative scale. Fairly high correlation coefficients were found between secretin-CCK test results and severity of acinar atrophy and small dilatation. These findings emphasize the importance of the secretin-CCK test for diagnostic and follow-up purposes in chronic pancreatitis.
These results suggest that blockade of CD11b/CD18-mediated mucosal neutrophil recruitment may form part of a strategy for targeted therapeutic intervention in inflammatory bowel disease.
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