SUMMARYA bioequivalence of two brands of 10% enrofloxacin was tested in broiler chickens using a parallel design at 20 mg/kg bodyweight orally. Blood was sampled before and after drug administration for 24 hours. Plasma enrofloxacin concentrations were analyzed using microbiological assay. Peak plasma concentrations (C max ), 1.00 ± 0.05 and 0.91 ± 0.02 μg/ml were obtained in chickens given Reference and Test brands respectively at 1.00±0.01 and 2.00 ± 0.17 hours respectively. Areas under plasma concentration-time curve (AUC0-24) were 3.79 ± 0.07 and 4.90 ± 0.01 μg/ml for Reference and Test brands respectively. Ratios of C max , and AUC 0-24 (T/R) were 0.91 and 1.29 respectively. These are within the bioequivalence acceptance range. conflox ® -vet and kenflox ® are therefore bioequivalent and interchangeable.
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