Application of FG altered collagen deposition around the fascia grafts, leading to significantly increased collagen density after 90 days. Differences found in the composition of the extracellular matrix in later stages of the healing process are a result of changes that occur in the beginning of this process. Therapeutic interventions, such as the use of FG and/or its components, performed in the early stages of wound healing may interfere with the complex interactions of fibroblasts, inflammatory cells, and cytokines (especially TGF-beta), thereby modulating the healing process.

Introduction: Knowledge about effective vocal techniques will contributes to the prevention/treatment of work-related voice disorder. Purpose: Verifying acoustic vocal, auditory-perceptive and videolaryngostroboscopic measures in dysphonic teachers of two groups before and after a brief and intensive therapy program with finger kazoo technique, comparing to their control groups, and comparing the study groups between themselves. Methods: Randomized study, pre-test and post-test, with control group, blind to the evaluator. Two study groups, with and without structural laryngeal affection (24 dysphonic teachers) performed15 sessions of a brief and intensive care with finger kazoo over three weeks and they were compared to two control groups (17 dysphonic teachers), who did not do therapy, in a total of 41 subjects. We carried out vocal acoustic analysis (Multi-Dimensional Voice Program Advanced), perceptual analysis (by three speech therapists) and videolaryngostroboscopy analysis (by three otolaryngologists) to compare the results obtained by each group. Results: Significant reduction in harmonic-noise ratio in the study group with alteration after therapy was observed. In the comparison between the study group without affection with the respective control, there was a significant decrease in jitter, shimmer and voiceless segments in favor of the study group. It was also observed a significant reduction in dysphonia, hoarseness, breathiness and tension levels, as well as a lower incidence of triangular slit -level II -and higher amplitude of vibration of the vocal folds in the study group with alteration. Conclusion: The brief and intensive care with finger kazoo provided voice, glottal closure and amplitude of mucosal wave vibration of the vocal folds improvements in dysphonic teachers with and without structural alterations of the vocal folds, especially in teachers without structural alterations.

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Modelo do estudo: Caso-controle. Objetivos do estudo: Comparar a capacidade funcional, parâmetros respiratórios e qualidade de vida entre sujeitos saudáveis e pacientes com apneia obstrutiva do sono. Metodologia: Em 19 pacientes com apneia obstrutiva do sono e 19 sujeitos saudáveis foram avaliadas a qualidade de vida (The Medical Study 36-item Short-Form Health Survey), capacidade funcional (teste de caminhada de seis minutos), função pulmonar (espirometria) e força muscular respiratória (manovacuometria). Resultados: Os pacientes apresentaram declínio na qualidade de vida pelos domínios capacidade funcional, estado geral de saúde e saúde mental. A distância percorrida no teste de caminhada de seis minutos foi menor nos pacientes com apneia obstrutiva do sono. Os parâ- metros respiratórios não diferiram entre os grupos. Conclusão: Pacientes com apneia obstrutiva do sono apresentam comprometimento da qualidade de vida e da capacidade funcional