Introduction: Street children still become a big concern in the world, and United Nations has concerns about a homeless child or live-in poverty. Dysfunction of the family process has the worst implication for the child as a vulnerable population. It does not only increase anxiety and depression but also leads to self-neglect especially among street children. The nurse especially the mental health nurse and community nurse needs to identify the risk factor of dysfunctional family process and self-neglect to make possible prevention and intervention for street children. This study aims to determine the correlation between the dysfunction of the family process and the self-neglect of street children in Yogyakarta. Methods: The sample was 90 street children who are from the district in Yogyakarta. The sample was taken by accidental sampling technique, with the sampling criteria: 1) the street children who live in Yogyakarta, 2) willing to fill inform consent, 3) both boys or girls, 4) age 10-21 years old, 5) not marriage yet. The instrument was using a dysfunction of family process questionnaire and self-neglect questionnaire which are both are developed from NANDA-I Nursing Diagnoses. The data analysis was used Pearson Correlation Test. Results: The mean score of dysfunctions of the family process is 109 and self-neglect has a mean score of 28.33. There was a significant relationship between dysfunction of family process and self-neglect among street children in Yogyakarta (p= 0.000) with a correlation coefficient were 0.659. Conclusions: There was a significant relationship between dysfunction of family process and self-neglect among street children in Yogyakarta