No abstract

Monosodium glutamate (MSG) is one of additive compounds that can easily cross the placenta and affect brain development. The current study aims to investigate the detrimental effects of monosodium glutamate (MSG) on Albino Swiss Mice Mus musculus fetal brain during pregnancy and after delivery. Forty-eight pregnant mice were divided into two groups: control group(24) received only distilled water while the second group (treated group 24 mice) received 0.2ml/daily of MSG solution from the 17th days of pregnancy until the 21st days after birth (lactation period). Infant mice were randomly selected from each group and sacrificed in 15th, 21st, 30th and 60th days after birth. Histopathological examination of brain showed significant differences between treated and control groups. Histological lesions including: megakaryocyte, necrosis, blood capillary stenosis, fraction of nerve fiber and blood capillary collapsing, eosinophil cell, medullary necrosis and necrosis, eosinophilic nerve fiber, horseshoe shape nucleus, rosette shape pattern, acidophilic cytoplasm, swelling cell, gliosis, coalesces and occluded blood vessel. In conclusion, monosodium glutamate has clear histological effects on the brain of infant mice.

The study include effect therapeutic dose of metformin drug in blood sugar of pregnant mice treated with folic acid. Mice weight ranged (25±2) g with age (12-16)weeks ,The concentrations of uesd were (0.18 & 0.53) mg \ 25 gm mice body weight which corresponded to (500&1500) mg\70 Kg of body weight in adult human , The therapeutic dose of folic acid used was (0.002) mg\mice body weight which corresponded to (5) mg \ body weight in human , was aimed to define the effects of drugs in sugar level during pregnancy with the presence of folic acid or its absence , The drug was orally administrated , at (6-18) th day of pregnancy while folic acid was administrated at (4-18) th day. This group was treated with metformin drug after 2 hours of folic acid admimstration at (6) th day , The administration was once in the morning of each , The results showed non significant decrease in the sugar level in groups treated with metformin while significant increase in groups treated with metformin drug and folic acid compared with control.

The study included the effect of metformin drug over dose in the liver pregnant non-Diabetic mice with weight ranged (25±2) gm , Orally administration of (1.8 , 2.85) mg of drug from (6-18) th day of pregnancy in the morning and once time daily, Drug caused death in half number of animals in 8.1)) mg concentrate and caused significant increase in liver weight in high concentration 2.85 mg and non significant in low concentration compared with control group (non treated) , In addition some histologically changes that included inflammatory cells around damaged blood vessels which increase with high dose caused primary biliary cirrhosis. Other changes include Degeneration , necrosis , Blood vessels damage ,Greenish, Congestion and hemorrhage and fibrosis in the liver of dead mice .