Background: There are few data in the paediatric literature on the normal Cortisol response to stimulation during the low dose synacthen test (LDST) (1 pg). Aim: To examine the Cortisol responses in children, subsequently presumed to be normal, who had an LDST during anterior pituitary function tests (APFTs).
Methods: A retrospective review of results in children with short stature and normal growth hormone levels.Results: Of 33 children tested, seven had suboptimal Cortisol responses based on accepted criteria (peak <500 nmol/1) -a false positive rate of 21%. Only three of these children had a repeat LDST, which was normal in all cases. The peak Cortisol response (median 633, range, 417-1052 nmol/1) was inversely correlated with age (r = -0.44, ρ <0.05). Conclusion: One in five tests did not meet normal criteria. This false positive rate (21%) should be borne in mind when interpreting synacthen tests to prevent overdiagnosis of adrenal insufficiency.
KEY WORDSlow dose synacthen, adrenal insufficiency
AbstractsBackground Childbirth is a remarkable experience in the life of women and her family, so health professionals (obstetric doctor and nurse), should adopt a set of practises that promote healthy labour and birth, including respect for the physiological process and dynamic of each birth. Objective To analyse the relationship between sociodemographic and obstetric variables with the valorisation of care received during labour and postpartum. Method A quantitative, cross-sectional, descriptive and correlational study, consisted of 386 women interned in the obstetrics service of the Portuguese public hospitals who received a questionnaire consisting of sociodemographic variables, care provided, action before pain, social and familial support, attention to wellbeing and attention to postpartum/discharge. Results The puerperal women were aged between 19 and 37 years, mostly married (79.5%). 34.5% have secondary education, 70.2% perform a work activity and 50% are primiparous. Parity, surveillance of pregnancy, preparation for childbirth and parenting time and hours in labour (this inversely), influence the importance of the care received in relation to the action before the pain and attention to the wellbeing. Conclusion The orientation of obstetric care according to the woman allows for active participation in her birth plan, a sense of control, improves her self esteem and their level of satisfaction with the care received.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.