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Objectives: To identify the risk factors of delayed extubation after cardiac surgery.Study Design: Observational study. Setting: Cardiac surgery in CPE Institute of Cardiology.Period: 2 months from November-2016 to March-2017. Methods: Eighty-one (81) patients whounderwent cardiac surgery. In ICU we recorded extubation time of all patients. Patients withextubation time <6 hours after labelled as early extubation group and those with extubationtime >6 hours were labelled as delayed extubation group. We recorded their preoperative riskfactors and operative variables of surgery to identify the risk factors that leads to late extubationafter cardiac surgery (CS). Results: Prevalence of diabetes was significantly high in patientswith delayed extubation. There were 42.3% diabetic patients with delayed extubation and only12.7% diabetic patients with early extubation (p-value 0.003). Total pump time, cross clamptime and type of operation were similar between the groups. Cardiovascular instability wasthe most common cause of delayed extubation that occurred in 9 patients, reduced level ofconsciousness in 9 patients, post-op bleeding in 6 patients, while hypoxemia and increasedrespiratory rate occurred in 1, 1 patient respectively. Conclusion: Diabetes Mellitus is anindependent risk factor of delayed extubation after cardiac surgery. Cardiovascular instability,reduced level of consciousness and post-operative bleeding after surgery are the main factorsthat leads to delayed extubation after CS.