Introduction: Chondrolipomas are rare, benign mesenchymal tumors characterized by proliferation of mature adipocytes associated with variable amounts of mature cartilaginous tissue. Chondrolipoma of the oral cavity is an uncommon clinical presentation. Case Report: We present the case of a 50-year-old, male, Nigerian, type 2 diabetic presenting with a painless, slow growing swelling of the lower lip of two years duration which did not respond to antibiotic therapy. Excision and histopathologic assessment of the mass revealed a diagnosis of chondrolipoma. Conclusion: Chondrolipoma should be included in the differential diagnosis of masses in the oral cavity.