Background: Diabetes mellitus is the most common endocrine pathology. According to the World Health Organization, non-compliance patients, especially with long-term medication prescriptions for diabetes, have become a serious healthcare concern. Methods: We conducted a cross-sectional study in the western region of Saudi Arabia from February to April 2022. The online questionnaire distributed through social media included questions on compliance among diabetic patients attending a primary health center. We entered the data automatically into an Excel spreadsheet and used the Statistical Package for the Social Sciences for the analysis. Results: We surveyed 526 diabetic patients from western Saudi Arabia. Participants aged more than 50 years old represented the majority of responses (36.1%). Most of the participants had type 2 DM (52.85%). Moreover, most diabetic patients complied with diabetic clinics. Conclusion: Our findings show an adequate level of diabetic patients' compliance. Future studies must address the related influencing factors for non-compliance patients to enhance patients' health outcomes.