To investigate the effects of foliar applications mulberry leaf enzyme solution fertilizer on growth, nutritional quality, photosynthetic characteristics, mineral elements, and antioxidant enzyme system of hydroponic Chinese cabbage, Chinese cabbage Zheng bai'886'was used as experimental material. In this study, we mainly selected seven different fermentation periods (CK: Distilled water, T1-T6, the fermentation days were 20, 35, 50, 65, 80, and 95 d) of mulberry leaf enzyme solution as foliar fertilizer on the effects of hydroponic Chinese cabbage. The results showed that plant height, plant width, leaf area, maximum root length, fresh and dry weight, soluble sugar, soluble protein, Vc, anthocyanin content, and photosynthetic capacity of Chinese cabbage were significantly increased compared with CK when spraying fermented for 50 d mulberry leaf enzyme solution and nitrate nitrogen content in Chinese cabbage decreased significantly. Compared with CK, the accumulation of calcium, magnesium, and iron in the shoot increased by 56.58, 50.70 and 36.67%, respectively, and antioxidant enzyme activities (SOD, CAT, POD) of Chinese cabbage was improved by spraying fermented for 50 d mulberry leaf enzyme solution. In general, sprayed fermented for 50 d mulberry leaf enzyme solution has a relatively good effect on hydroponic Chinese cabbage.