Objective: Determine the healthy lifestyle and work stress in Nurses who care for patients with COVID -19, at the National Institute of Neoplastic Diseases, Lima, 2020. Study: Quantitative, correlational, cross-sectional approach and non-experimental design. Population: it was made up of the 65 nurses who work in the Covid-19 area. Instruments: 2 questionnaires were used: Healthy lifestyle, consisting of 3 dimensions: physical activity, eating habits, sleep dimension. Work stress, which consists of 3 dimensions: emotional exhaustion, depersonalization and personal fulfillment. Both instruments with Likert scale were validated by expert judgment with a reliability of 0.8 and 0.7 respectively. The results found that there is a correlation between both variables. In addition, it predominates in nurses who mostly have inadequate healthy lifestyles. Also, the moderate level of stress is a problem affected in their emotional health in times of pandemic. It is concluded that it is important before these health problems require the implementation of improvement plans to promote self-care and avoid occupational health problems.