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Glutathione S-transferases (GSTs) are major intracellular antioxidants, which, impaired in their function, are involved in the progress of schizophrenia (SCZ). The aim of this case-control study was to investigate the association between the polymorphism of glutathione S-transferases M1 (GSTM1), T1 (GSTT1), the glutathione S-transferase P1 gene (GSTP1) and SCZ. We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. The analysis of the gene-gene interaction between GSTs indicated that the magnitude of the association was greater for the combined AG/GSTT1 & GSTM1 genotypes (OR = 2.51; 95% CI: 1.13-5.63, P = 0.02). The AG and combined AG + GG genotypes of GSTP1 increased the risk of SCZ (OR = 1.83; 95% CI: 0.94-3.75 and OR = 1.71; 95% CI: 0.92-3.19, respectively). The genotypes of GSTT/NULL, NULL/GSTM and NULL/NULL increased the risk of SCZ (OR = 2.05; 95% CI: 0.9-4.74; OR = 2.0; 95% CI: 1.68-2.31; and OR = 1.8; 95% CI: 0.57-2.46, respectively). The present study supports previous data that suggest that impairment in the function of GSTs genes may increase the risk of SCZ.

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Background- Effective interventions to improve sexual dysfunction in breast cancer survivors need screening of these dysfunctions with a suitable instrument. The aim of present study was translation and identifying psychometric properties of FSFI-BC which has been specifically developed for breast cancer survivors. Method-Forward and backward method was used for translating of the scale from English into Persian. 200 breast cancer survivors in stage 1 or 2 completed the questionnaire. Reliability was assessed by Cronbach’s alfa and test re-test analysis and construct validity with confirmatory and exploratory factor analysis.Results-The mean age of participants was 48.91(SD=9.758). Most women were housewives (74%) and mastectomy had been performed for 58% of them. Reliability evaluation indicated high internal consistency and good test re-test reliability. Confirmatory factor analysis showed an acceptable fitness for seven factor of FSFI-BC questionnaire (NFI= 0.9 for both groups, CFI= 0.93 and 0.92 , χ2/df= 1.68 and 1.71 for SA(Sexually Active) and NSA(No Sexually Active) individuals respectively) .Conclusion-Study findings suggest that Iranian version of FSFI-BC is a suitable instrument for sexual dysfunction screening in breast cancer survivors.