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Multicomponent reactions Multicomponent reactions O 0359Novel α-Amino Amidine Synthesis via Scandium(III) Triflate Mediated 3CC Ugi Condensation Reaction. -The title compounds are prepared via a novel Sc-catalyzed multi-component reaction involving aldehydes, amines and isonitrile (III). This approach is extended to the synthesis of a imidopyrazine derivative (VI). -(KEUNG*, W.; BAKIR, F.; PATRON, A. P.; ROGERS, D.; PRIEST, C. D.; DARMOHUSODO, V.; Tetrahedron Lett. 45 (2004) 4, 733-737; Dep. Chem., Senomyx, Inc., La Jolla, CA 92037, USA; Eng.) -M. Paetzel 15-064

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Pyridine derivatives Pyridine derivatives R 0380A Facile Synthesis of Racemic 2-Aminomethyl-4-oxo-piperidine Intermediates.-A facile access to the useful 2-substituted 4-oxopiperidine scaffold via a hetero Diels-Alder reaction between an appropriately functionalized imine and 3-silylbutadiene (III) is described. -(HOLSWORTH*, D. D.; BAKIR, F.; UYEDA, R. T.; GE, Y.; LAU, J.; HANSEN, T. K.; ANDERSEN, H. S.; Synth.