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Herein, the unzipping and translocation of DNA duplexes through a sub-2 nm silicon nitride (SiN) solid-state nanopore have been demonstrated by well-resolved three-level blockades. In order to examine our observations, we applied a simple model which is applicable to the unzipping and translocation processes of DNA duplexes through solid-state nanopores. The generation of these highly recognizable signatures is an important step towards the real applications of solid-state nanopores in complex samples.

A simple electrochemical method has been proposed for the preparation of silver nanoparticles that can be used for the detection of cyanide. Both the electrochemical behavior and morphology of the Ag nanoparticles have been characterized in the presence of KCN or diethyl cyanophosphonate (DECP) as well as in alkaline media. These were investigated by cyclic voltammetry and scanning electron microscopy (SEM). DECP is a simulant of the chemical warfare agent tabun.