Chitosan-coated magnetic nanoparticles are an appropriate drug delivery method which can improve the therapeutic properties of chemotherapy agents and also can be useful as MRI contrast agent for early cancer diagnosis. This research discovers the optimization of the possible therapeutic effects of Chitosan- citric acid- Fe3O4- CUR quartets. Chitosan as a natural polymer can use to encapsulate citric acid modified Fe3O4 nanoparticles. The successful preparation of CUR-loaded nano-carriers was confirmed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM) techniques. Moreover, the hemolysis test was used for the study of hemobiocompatibility. The loading capacity and encapsulation efficiency of CUR molecules were 11±0.09% and 49.5±0.41%, respectively. The anticancer effect of the void of CUR and CUR-loaded nano-carriers were compared by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the treated MCF-7 cell lines. It can be concluded that the use of these nanoparticles are a better and more efficient approach for the controlled and slow release of CUR in the cancer treatment.

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Background and Aim: Periodontal diseases and dental caries are two of the most common oral health problems. The present study was carried out to evaluate the oral and dental health indices of sixth grade primary school students. Materials and Methods: In this cross-sectional study, 162 male and female students were randomly selected in two steps from traditional primary schools and health-promoting schools (HPSs) in Hashtgerd City, Alborz Province, Iran. Demographic information and oral health behaviors were recorded. Examinations were performed by one person, and the decayed, missing, and filled teeth (DMFT) index and oral hygiene index simplified (OHI-S) were checked and recorded in the standard form of the World Health Organization (WHO). Data were analyzed by the t-test and Pearson correlation coefficient. Findings: The mean DMFT was 1.83 ± 2.17. There was no significant difference between genders. The mean OHI-S was 1.40 ± 0.57. Oral hygiene was good for girls, and it was moderate for boys, in which this difference was significant (p < 0.001). The relationship between DMFT and OHI-S in the total population was statistically significant (p < 0.01). DMFT and OHI-S were higher in the traditional schools than in HPSs.