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Background and AIM: Microgap formation at implant-abutment connection is one of the complications leading to mechanical and biological failure and inflammation around implants. This study aimed to investigate the influence of GapSeal as a sealing material on the extent of microgap and microleakage at the internal hexagon implant platform. Materials and Methods:Sixteen implants with an internal-hexagon connection (Biohorizon, internal hexagon) were employed in this in-vitro experimental study. All implant-abutment sets were assigned to two groups and were molded in acrylic resins. GapSeal was injected into the implants in the experimental (test) group. Then, implant assemblies were tightened with the torque of 30 N/cm, and 1200,000 loading cycles with the force of 100 N and the frequency of 1 Hz were applied. Every sample was immersed in a methylene blue dye to evaluate microleakage. Microgap was measured in six regions randomly using a scanning electron microscope (SEM). The data were entered into SPSS 22 and were analyzed using t-test. Results:The mean±SD microgap was 0.99±0.39 µm and 3.04±0.54 µm in the test and control groups, respectively. It was higher in control group, significantly.(P<0.0001) In addition, microleakage was observed in all of the specimens of the control group, while no microleakage was seen in the test group. A significant statistical difference was found between the groups regarding microgap and microleakage (P<0.0001). Conclusion:Application of GapSeal® reduced the dimension of the microgap and decreased microleakage at the implant-abutment interface.

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