Background: Future sustainable energy industrialization is a green energy source that has a lower circumstantial impact than traditional energy technologies. The advancement of new energy generation is important to expand the share of renewable energy sources. Objective: Worldwide, for the next generation, future energy demand may be fulfilled by using one of the renewable energy sources such as thermo electricity. Methods: The bismuth telluride-based (Bi2Te3-based) nanostructure material in thermo electricity stillhas a major part of applications. It is known as the most prospective TE device manufactured from a research arena towards successful commercialization. Results: The Bi2Te3-based nanostructure material is now on commercialization stages that it has some limitations. In order to find out the future direction of research and development of this material, the material will face a challenging way. Conclusion: The review paper provides an effective approach to overcome the limitation of Bi2Te3-based nanostructure. Moreover, in this review paper, the performance evaluation with existing Bi2Te3-based nanostructure and some other TE materials will be discussed in detail.