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In Acute Myeloid Leukemia (AML) patients, a diversity of clinical and hematological parameters has been examined for possible value in calculating treatment response and survival. The study was conducted at National Institute of Bone Diseases, Karachi (NIBD), Sind, Pakistan, a tertiary care and teaching hospital, affiliated with Liaquat University of Medical and Health Sciences, Jamshoro. This study included 107 cases of de novo AML, both male and female patients of ages between 10-60 years were selected randomly. The clinical features included fever, weakness, loss of weight, vomiting, bleeding gums, liver and spleen enlargement, lymph node enlargement. The Laboratory investigations included CBC (Complete Blood Count) specifically heamoglobin percentage, total leucocyte count, platelet count and blast count: peripheral blood smears, bone marrow aspiration biopsy, trephine biopsy, cytochemistry (Myeloperoxidase Staining, Immunohistochemistry (CD markers)) and DNA extraction for genetic sequencing. Percentage, validity and cumulative index were calculated of all parameters. It was found that about 70% of AML patients were adults and FAB subtype M2 of acute myeloid leukemia was more prevalent than other subtypes, followed by AML, M1.

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Breast lump is the common complaint of women in clinics, which includes the second leading cause of cancer deaths in women.Objective: The study was conducted to know the pattern of female breast diseases in our setup at Hyderabad / Jamshoro. Design: Adescriptive Study. Setting: Liaquat University of Medical and Health Sciences, Jamshoro. Material & Methods: Descriptive study Setting: Itwas conducted in the department of pathology, Liaquat University of Medical and Health Sciences, Jamshoro. Period: Ten years from January2001 to December 2010. Results: Total of 2693 breast biopsies and mastectomies specimen included in this study, of which 278(10.32%)fibrocystic changes, 507(18.83%) inflammatory, 983(36.5%) benign and 889(33.01%) malignant. Conclusions: Benign Breast disease;fibroadenoma was the most common lesion. Infiltrating ductal carcinomas were next frequent, which reached hospital at late stage of disease.