Granular Cell Tumor (GCT) is an uncommon, benign tumor of neural origin resembling Schwann cells. It is more common in females and blacks. Head and neck regions are the most sites involved by the tumor, but it can occur in any part of the body. Vulva, ovary and cervix in females and scrotum in males can present GCT. The importance of this tumor is potential malignant transformation in rarity. Total excision is the choice treatment for GCT because of probability of recurrences.In this article, we described a case of granular cell tumor of the labium majus in a 21-year old lady, from southwest of Iran. Subsequent investigations confirmed positive results for S100 protein and neuron specific enolase, but Periodic Acid Schiff (PAS) staining was negative.Our findings confirmed neural origin for GCT.

Subungual Squamous Cell Carcinoma (SCC) is the most common malignancy affecting the nail bed. About 150 cases of subungual SCC have been reported in the literature. It usually involves the thumb, the index finger and only rarely, the toes.Subungual SCC runs an indolent course and may present with minimal symptoms. Diagnostic confusion emerges because many chronic lesions of the nail bed may be clinically similar to SCC.Although SCC of the nail bed is considered a low-grade malignancy, bone invasion and metastasis to the regional lymph nodes may occur.Herein, we reported a case of subungual toenail SCC with bone involvement and a 6-year delay between its appearance and diagnosis.

A common intramacrophage niche for leishmanial and mycobacterial pathogens, and a similar spectrum of immune response and disease phenotypes, led to the prediction that the same genes/candidate gene regions might be responsible for genetic susceptibility to mycobacterial infections. There are several reports of atypical cutaneous presentation of leishmaniasis such as paronychial, whitlow, lid, scar, palmoplantar and chancriform in immunocompetent patients. Numerous Leishmania organisms were observed within the histiocytes and extracellular in patient suffering from swelling, pain and itching. An unknown strain of mycobacterium was also isolated from biopsy specimen of the patient. Phenotypic and molecular tests carried out for identification of the strain based on standard methods. The susceptibility of the strain to anti-mycobacterial agents was performed by CDC standard Method. Numerous Leishmania organisms were observed within the histiocytes and extracellular space. PCR amplifications tests for detection of leishmania have been positive. Acid-fast staining and culture tests have been positive. PCR amplifications tests for detection of M. tuberculosis and M. avium have been negative. Phenotypic tests mainly including, positive result for growth at 25°C and 37ºC and PNB test,