Infectious agents cause 15-20% of cancers worldwide. The contamination of infectious agents may be caused by a local chronic inflammatory response or tumorization. Mycoplasma contamination can interfere with biological agents and cause DNA damage which affects gene expression, disrupts the cell-cycle control and apoptotic responses. Mycoplasmas are widely distributed in nature; some mycoplasmas have the ability to penetrate into the cell and cause sever disease. Most mycoplasmas are known to infect the cell culture media, which is difficult to detect the contamination.M. hyorhinis is one of the main reasons the Mycoplasma contamination in tissues samples from cancer patients. Mycoplasma is related to human cancers and some other human diseases. Several studies have shown that M. hyorhinis potentially plays a role in esophageal, gastric, lung, breast, glioma, colon, and prostate cancers. The prevalence of M. hyorhinis in various tissues leads to cancer progression. Therefore, it is necessary to pay more attention to this mycoplasma agent in order to control and understand its mechanism.Article Info