Osteoporosis is increasingly being recognized by the medical fraternity as a significant health problem. This research was designed to study the incidence of osteoporosis in post-menopausal women and its relation to body mass index, body muscles, body fat and mineral status (calcium and phosphorus). Thirty samples of post-menopausal women aging between 45-60 years were divided into 3 groups. Body weight and height seemed to be tested through the use of electronic weighing balance and Stadiometer. Body muscles and fat percentage were determined through Beurer GmBH BLACK Blr.64. Bone mineral density was calculated by bone densitometry. Serum concentration of calcium and phosphorus was determined by spectrophotometer. The data obtained was subjected to Analysis of Variance. Results showed the significant decrease in body muscle, bone mineral density and serum calcium with increasing age. It was concluded that body weight, body muscles, body fat, bone mineral density, serum calcium and phosphorus had significant association with age and osteoporosis. Body fat and serum phosphorus increases with age in post-menopausal women. Body mass index and height had non-significant association with age and osteoporosis.