Background:Self-immolation is a high risk behavior and a way of life termination. Self-immolation, as the most painful of all forms of suicide, is not a common form of suicide in European countries. However, it is highly prevalent in developing countries particularly in Asia and Africa.Objectives:The aim of this study was to assess the rate and leading factors of self-immolation and gender, geographical distribution, and social norms of affected patients referred to Khatamolanbia Hospital of Zahedan from March 2010 to May 2012.Materials and Methods:This descriptive and objective-based study was cross-sectional and retrospective with 750 burn patients; 315 of them had attempted self-immolation and most of them died. The data collection tool was a two partite questionnaire consisting of 17 questions (8 questions about personal details and 9 questions about self-immolation factors).Results:350 self-immolations resulting in death were reported in this study; these subjects were 16-25 years old, 67.25% female, 63.55% elementary school education, 74.20% married, 69.10% housewife, 61.05% resident of Saravan, 93.35% oil burns, 72.30% middle and low social class, 90.20% burn over 68%, 20% psychiatric illness history and being treated with antidepressants, 73.25% verbal and physical violence before burning, and 100% of the burnings took place inside a house and usually during the afternoon.Conclusions:Due to the high rate of self-immolations in this area, solutions for improvement of life quality and social norms should be reviewed and implemented.