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Background: Mini puberty is the important period of infancy life that has several impressions to sexual development in both sexes. In the infants born very premature and extremely low birth weight, mini puberty changes including clinical, hormonal and imaging data are severe and long lasting, especially in girls. It can be called “exaggerated mini puberty”.Methods: In this study, 6-month preterm infant with bronchopulmonary dysplasia presented with periodic vaginal bleeding, breast stage tanner 3 and pubic hairs. We followed up infant by clinical and para clinical evaluations during one year and compared this data with all of the similar articles were published.Results: During one year monitoring of the infancy puberty presentation, gradually returned to the pre pubertal state, without excessive hormonal treatment. Conclusions: Due to this systematic review, exaggerated mini puberty is the temporary physiologic state in very low birth weight preterm infants that should be prevents any extra hormonal and surgical intervention.

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